منابع مشابه
GATOR1 regulates nitrogenic cataplerotic reactions of the mitochondrial TCA cycle
The GATOR1 (SEACIT) complex consisting of Iml1-Npr2-Npr3 inhibits target of rapamycin complex 1 (TORC1) in response to amino acid insufficiency. In glucose medium, Saccharomyces cerevisiae mutants lacking the function of this complex grow poorly in the absence of amino acid supplementation, despite showing hallmarks of increased TORC1 signaling. Such mutants sense that they are amino acid reple...
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Cellular metabolic demands change throughout the cell cycle. Nevertheless, a characterization of how metabolic fluxes adapt to the changing demands throughout the cell cycle is lacking. Here, we developed a temporal-fluxomics approach to derive a comprehensive and quantitative view of alterations in metabolic fluxes throughout the mammalian cell cycle. This is achieved by combining pulse-chase ...
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mutation in torsinA, an AAA ATPase protein, causes DYT1 dystonia in humans. On page 855, Goodchild and Dauer identify two protein binding partners of torsinA, one that localizes to the ER membrane and one that spans the inner membrane of the nuclear envelope. The team hypothesizes that DYT1 is a nuclear envelope disease , and that identification of such protein complexes will provide a mechanis...
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Inborn defects of the tricarboxylic acid (TCA) cycle enzymes have been known for more than twenty years. Until recently, only recessive mutations were described which, although resulted in severe multisystem syndromes, did not predispose to cancer onset. In the last ten years, a causal role in carcinogenesis has been documented for inherited and acquired alterations in three TCA cycle enzymes, ...
متن کاملNMR study of gluconeogenesis and TCA cycle flux in humans
JOHN G. JONES,1 MICHAEL A. SOLOMON,2 SUZANNE M. COLE,3 A. DEAN SHERRY,1,3 AND CRAIG R. MALLOY1,2 1Department of Radiology, University of Texas Southwestern Medical Center, Dallas 75235; 2Department of Internal Medicine, University of Texas Southwestern Medical Center and Department of Veterans Affairs Medical Center, Dallas 75216; and 3Department of Chemistry, University of Dallas, Richardson, ...
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ژورنال
عنوان ژورنال: Nature Cell Biology
سال: 2011
ISSN: 1465-7392,1476-4679
DOI: 10.1038/ncb2361